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Regulation of breast cancer resistance protein and P-glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines.
Yano K, Okabe C, Fujii K, Kato Y, Ogihara T. Yano K, et al. J Pharm Pharmacol. 2020 Apr;72(4):575-582. doi: 10.1111/jphp.13225. Epub 2020 Jan 24. J Pharm Pharmacol. 2020. PMID: 31975441
KEY FINDINGS: In HCC827 cells, the efflux rates of SN-38 and Rho123 were significantly decreased by knockdown of Ezr or Msn, but not Rdx. However, BCRP function was unaffected by Ezr or Rdx knockdown in Caco-2 cells, which do not express Msn. In Caki-1 cells, Rdx …
KEY FINDINGS: In HCC827 cells, the efflux rates of SN-38 and Rho123 were significantly decreased by knockdown of Ezr or Msn, but not Rdx …
Correlations of mRNA Levels among Efflux Transporters, Transcriptional Regulators, and Scaffold Proteins in Non-Small-Cell Lung Cancer.
Zhang X, Liu W, Edaki K, Nakazawa Y, Kamioka H, Fujita A, Onozato R, Iijima M, Tsuchida S, Arai T, Fujita Y, Mizoi K, Ogihara T. Zhang X, et al. Can J Infect Dis Med Microbiol. 2021 Nov 28;2021:4005327. doi: 10.1155/2021/4005327. eCollection 2021. Can J Infect Dis Med Microbiol. 2021. PMID: 34876945 Free PMC article.
We recently showed that increased activity of the efflux transporter P-glycoprotein (P-gp) associated with activation of Snail transcriptional regulators may be mediated mainly by moesin in lung cancer cells. Here, we aimed to systematically evaluate the relationships amon …
We recently showed that increased activity of the efflux transporter P-glycoprotein (P-gp) associated with activation of Snail transcription …
Mechanism of Induction of P-gp Activity During MET Induced by DEX in Lung Cancer Cell Line.
Liu W, Zhang X, Sunakawa H, Perera LMB, Martha L, Mizoi K, Ogihara T. Liu W, et al. J Pharm Sci. 2024 Mar 2:S0022-3549(24)00083-2. doi: 10.1016/j.xphs.2024.02.027. Online ahead of print. J Pharm Sci. 2024. PMID: 38432625
Lung cancer metastasis often leads to a poor prognosis for patients. ...MDR arises from the overactivity of drug efflux transporters such as P-glycoprotein (P-gp) which operate at the cell plasma membrane, under the regulatory control of the scaffold proteins ezrin (Ezr), …
Lung cancer metastasis often leads to a poor prognosis for patients. ...MDR arises from the overactivity of drug efflux transporters …
Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis.
Valastyan S, Chang A, Benaich N, Reinhardt F, Weinberg RA. Valastyan S, et al. Cancer Res. 2010 Jun 15;70(12):5147-54. doi: 10.1158/0008-5472.CAN-10-0410. Epub 2010 Jun 8. Cancer Res. 2010. PMID: 20530680 Free PMC article. Retracted.
miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was c …
miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alp …
Cytotoxic and genotoxic effects of energetic compounds on bacterial and mammalian cells in vitro.
Lachance B, Robidoux PY, Hawari J, Ampleman G, Thiboutot S, Sunahara GI. Lachance B, et al. Mutat Res. 1999 Jul 21;444(1):25-39. doi: 10.1016/s1383-5718(99)00073-x. Mutat Res. 1999. PMID: 10477337
Mutagenicity was evaluated with the Salmonella fluctuation test (FT) and the V79 Chinese hamster lung cell mutagenicity assay. Cytotoxicity was evaluated using V79 and TK6 human lymphoblastic cells. For the TK6 and V79 assays, TNB and 2, 4,6-triaminotoluene were more toxic …
Mutagenicity was evaluated with the Salmonella fluctuation test (FT) and the V79 Chinese hamster lung cell mutagenicity assay. Cytoto …
Characteristics and mechanisms of cardiopulmonary injury caused by mine blasts in shoals: a randomized controlled study in a rabbit model.
Han G, Wang Z, Wang J, Yang W, Chen J, Kang J, Zhang S, Wang A, Lai X. Han G, et al. PLoS One. 2013 Dec 16;8(12):e81310. doi: 10.1371/journal.pone.0081310. eCollection 2013. PLoS One. 2013. PMID: 24358110 Free PMC article.
In the experimental model, the water surface was at the level of the rabbit's xiphoid process, and paper electric detonators (600 mg RDX) were used to simulate mines. Electrocardiography and echocardiography were conducted, and arterial blood gases, serum levels of cardiac …
In the experimental model, the water surface was at the level of the rabbit's xiphoid process, and paper electric detonators (600 mg RDX …
Cytotoxicity and mutagenicity of a 2,4,6-trinitrotoluene (TNT) and hexogen contaminated soil in S. typhimurium and mammalian cells.
Berthe-Corti L, Jacobi H, Kleihauer S, Witte I. Berthe-Corti L, et al. Chemosphere. 1998 Jul;37(2):209-18. doi: 10.1016/s0045-6535(98)00039-3. Chemosphere. 1998. PMID: 9650264
The mammalian mutagenicity was tested with the HPRT test in V79 cells (hamster lung). The aqueous soil extract did not reveal toxicity or mutagenicity in any of the tests performed. ...
The mammalian mutagenicity was tested with the HPRT test in V79 cells (hamster lung). The aqueous soil extract did not reveal toxicit …
Suicide by head explosion: unusual blast wave injuries to the cardiovascular system.
Schyma C, Hagemeier L, Madea B. Schyma C, et al. Int J Legal Med. 2011 Jul;125(4):473-8. doi: 10.1007/s00414-010-0452-6. Epub 2010 May 12. Int J Legal Med. 2011. PMID: 20461526
The complete destruction of the head down to the cervical spine suggested that the explosive charge (RDX) detonated in his mouth. The hands were virtually uninjured. ...
The complete destruction of the head down to the cervical spine suggested that the explosive charge (RDX) detonated in his mouth. The …
Bioavailability of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) to the prairie vole (Microtus ochrogaster).
Fellows RJ, Driver CR, Cataldo DA, Harvey SD. Fellows RJ, et al. Environ Toxicol Chem. 2006 Jul;25(7):1881-6. doi: 10.1897/05-446r1.1. Environ Toxicol Chem. 2006. PMID: 16833151
Concerns have been raised over potential bioavailability and biotransfer of energetic materials such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). The present study assessed plant-incorporated [14C]RDX and plant-derived [14C]RDX-metabolite ingestion by th …
Concerns have been raised over potential bioavailability and biotransfer of energetic materials such as hexahydro-1,3,5-trinitro-1,3,5-triaz …
Role of arterial design on pulse wave reflection in a fractal pulmonary network.
Bennett SH, Goetzman BW, Milstein JM, Pannu JS. Bennett SH, et al. J Appl Physiol (1985). 1996 Mar;80(3):1033-56. doi: 10.1152/jappl.1996.80.3.1033. J Appl Physiol (1985). 1996. PMID: 8964721
A novel interpretation of pulmonary arterial input impedance was evaluated for the lung as a fractal vascular network. We hypothesized that local sources of reflection introduce trends of global reflection into the input impedance spectra. These trends are related to the n …
A novel interpretation of pulmonary arterial input impedance was evaluated for the lung as a fractal vascular network. We hypothesize …